منابع مشابه
Quinolinic acid neurotoxicity in the nucleus basalis antagonized by kynurenic acid.
Quinolinic acid, a metabolite of tryptophan, behaves as an excitotoxic amino acid. It has been proposed that quinolinic acid might be implicated in neurodegenerative diseases. The related metabolite, kynurenic acid, has been found to be a powerful antagonist of quinolinic acid. The ability of quinolinic acid, alone or in combination with kynurenic acid, to destroy cholinergic neurons projecting...
متن کاملQuinolinic Acid Metabolism
Since the observation (1) that tryptophan and nicotinic acid are mutually interchangeable, within limits, in supporting the growth of rats, considerable evidence has accumulated which indicates that biosynthesis of nicotinic acid can proceed from tryptophan (2-5). Unequivocal evidence for this transformation was provided by the experiments of Heidelberger et al. (6) who fed labeled tryptophan @...
متن کاملQuinolinic acid excretion and metabolism in man.
In 1946, Rosen e2 al. (1) showed that administration of tryptophan to rats resulted in an additional excretion of nicotinic acid and Nl-methylnicotinamide (Nl-Me). Singal et al. (2) found, in addition to these, increased excretion of another metabolite which could be converted to nicotinic acid by autoclaving in 1 N sulfuric acid solution. Henderson isolated this metabolite from the urine of ra...
متن کاملMetabolism and neuropathologic significance of quinolinic acid and kynurenic acid.
Neurologic symptoms and neurodegeneration are important causes of morbidity and mortality in man. Although many pathogenic mechanisms could account for neurologic dysfunction, considerable interest has focused on a group of neurotoxins known as the ‘excitotoxins’. Quinolinic acid (QUIN) is an excitotoxic L-tryptophan and kynurenine pathway metabolite that is an agonist of N-methyl-uaspartate (N...
متن کاملQuinolinic Acid: Neurotoxin or Oxidative Stress Modulator?
Quinolinic acid (2,3-pyridinedicarboxylic acid, QUIN) is a well-known neurotoxin. Consequently, QUIN could produce reactive oxygen species (ROS). ROS are generated in reactions catalyzed by transition metals, especially iron (Fe). QUIN can form coordination complexes with iron. A combination of differential pulse voltammetry, deoxyribose degradation and Fe(II) autoxidation assays was used for e...
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ژورنال
عنوان ژورنال: FEBS Journal
سال: 2012
ISSN: 1742-464X
DOI: 10.1111/j.1742-4658.2012.08493.x